Effectiveness of topical oxygen therapy as an adjunct in non-surgical periodontal treatment: A randomized clinical study
admin-cespu
Principal Investigator:
Marta Mendonça Moutinho Relvas
Leader Institution:
UNIPRO, U.CESPU
Research Team:
Filomena Salazar, Maria dos Prazeres Gonçalves, Rosana Costa, Alexandra Viana da Costa, José Adriano Costa,
Funding entity:
CESPU
Budget:
5377,05
Period covered:
01/09/2026-2027
Abstract:
Periodontitis is a multifactorial inflammatory disease characterized by the progressive destruction of the supporting dental tissues. Non-surgical treatment with subgingival instrumentation constitutes the first line of therapy. Topical oxygen therapy emerges as a promising adjuvant, modifying the subgingival microenvironment and inhibiting strict anaerobic bacteria through the local release of oxygen (Blue®m Oral Gel). The aim of this study is to evaluate the efficacy of the topical application of Blue®m Oral Gel as an adjuvant to subgingival instrumentation in controlling clinical periodontal parameters in patients with periodontitis. This is a randomized, controlled, longitudinal clinical study, with a split-mouth design and follow-up at 3 and 6 months. The sample included 40 adult patients with periodontitis. The clinical parameters assessed are: plaque index, bleeding on probing, probing depth, clinical attachment level, number of sites with pockets, and tooth mobility. Statistical analysis will be performed with IBM SPSS®, using the t-test for dependent samples, considering significance for p < 0.05.
Periodontitis is a multifactorial inflammatory disease characterized by the progressive destruction of the supporting dental tissues. Non-surgical treatment with subgingival instrumentation constitutes the first line of therapy. Topical oxygen therapy emerges as a promising adjuvant, modifying the subgingival microenvironment and inhibiting strict anaerobic bacteria through the local release of oxygen (Blue®m Oral Gel). The aim of this study is to evaluate the efficacy of the topical application of Blue®m Oral Gel as an adjuvant to subgingival instrumentation in controlling clinical periodontal parameters in patients with periodontitis. This is a randomized, controlled, longitudinal clinical study, with a split-mouth design and follow-up at 3 and 6 months. The sample included 40 adult patients with periodontitis. The clinical parameters assessed are: plaque index, bleeding on probing, probing depth, clinical attachment level, number of sites with pockets, and tooth mobility. Statistical analysis will be performed with IBM SPSS®, using the t-test for dependent samples, considering significance for p < 0.05.