Characterisation of the microbiome of the gingival crevicular fluid in patients with type 1 diabetes: diversity, structure and differential abundance of the bacterial communities.
admin-cespu
Principal Investigator:
Marta Relvas
Leader Institution:
UNIPRO, IUCS-CESPU
Research Team:
Marta Relvas, Filomena Salazar, Rosana Costa, Inmaculada Tomás, Carlos Balsa Castro, Alba Regueira Iglesias, Triana Blanco,
Funding entity:
CESPU
Budget:
5000 €
Period covered:
01/09/2025-2026
Abstract:
Type I diabetes mellitus (T1DM) is a chronic metabolic disease caused by the body's failure to produce insulin. The resulting hyperglycemic state causes chronic systemic inflammation that is harmful to health. Periodontal disease (PD) is a chronic inflammatory disease whose etiology is multifactorial. The relationship between these diseases has shown that PD potentiates the chronic inflammation that occurs during diabetes. In previous projects we describe the predominant medical parameters obtained by medical history and periodontal status. We also investigated the specific profile of the inflammatory response, and determined the salivary oral microbiome in diabetic patients diagnosed with PD and without PD, bearing in mind that the etiology of periodontal disease is related to the specific presence of oral bacteria. The oral microbiome of the crevicular fluid remains to be determined to see if there are any differences between this and the salivary microbiome of type 1 diabetic patients. A deeper understanding of the bidirectional relationship between PD and diabetes will contribute decisively to the determination of new treatment strategies and guide future lines of research.
Type I diabetes mellitus (T1DM) is a chronic metabolic disease caused by the body's failure to produce insulin. The resulting hyperglycemic state causes chronic systemic inflammation that is harmful to health. Periodontal disease (PD) is a chronic inflammatory disease whose etiology is multifactorial. The relationship between these diseases has shown that PD potentiates the chronic inflammation that occurs during diabetes. In previous projects we describe the predominant medical parameters obtained by medical history and periodontal status. We also investigated the specific profile of the inflammatory response, and determined the salivary oral microbiome in diabetic patients diagnosed with PD and without PD, bearing in mind that the etiology of periodontal disease is related to the specific presence of oral bacteria. The oral microbiome of the crevicular fluid remains to be determined to see if there are any differences between this and the salivary microbiome of type 1 diabetic patients. A deeper understanding of the bidirectional relationship between PD and diabetes will contribute decisively to the determination of new treatment strategies and guide future lines of research.