Orthodontic treatment must obey esthetic principles and occlusal stability (dynamic and static). Aligners as an orthodontic correction mechanism have changed the orthodontic paradigm, obeying the same general orthodontic principles, but more accepted by patients. Tooth movements performed with aligners in the 3 spatial planes require biomechanics defined from the beginning, and in the most complex and unpredictable cases, they require auxiliary means, such as mini-implants and movement accelerators, to achieve the goals planned by ClinCheck. In the multidisciplinary treatment of agenesis, after orthodontics with space opening, it is necessary to prosthetically replace the missing tooth. In the case of young patients, a minimally invasive rehabilitation, free from constant replacements, is imperative. Ceramic prostheses bonded with resin matrix-based cement can be durable and economically viable.