ComeTax-PFT-IINFACTS-2019: Targeting the mitotic protein p31comet for cancer therapy
admin-cespu
Principal Investigator:
Hassan Bousbaa (hassan.bousbaa@iucs.cespu.pt)
Leader Institution:
CESPU
Research Team:
Hassan Bousbaa, Bruno Sarmento, Ana Henriques, Patrícia Silva
Funding entity:
CESPU
Budget:
3.000€
Period covered:
03/2019 - 02/2020
Abstract:
Interfering with mitosis in cancer cells leads to mitotic arrest and, very often, to cell death. This explains the proven success of the antimicrotubule drugs like taxanes in the treatment of many cancers. However, their clinical efficacy has been impaired by side effects and drug resistance, highlighting the need of search for new anticancer agents.
Interfering with mitosis in cancer cells leads to mitotic arrest and, very often, to cell death. This explains the proven success of the antimicrotubule drugs like taxanes in the treatment of many cancers. However, their clinical efficacy has been impaired by side effects and drug resistance, highlighting the need of search for new anticancer agents.
Project area: